The nearest airport located to Middletown is the TF Green Airport located outside Providence, Rhode Island. All major airlines provide service to the airport, including a number of non-stop flights. Providence is located about 35 miles to the north of Middletown. Major car rental agencies, including National, Hertz, Enterprise, among others, are located at the airport.

The nearest Amtrak  stations to Middletown are located in Providence and West Kingston. Rental car facilities are located near to both stations. Bus service is another option. The Rhode Island Public Transit Authority provides service out of Providence.

When traveling by car, you can reach Middletown by taking I-95 to  highway 138 from the northwest, I-195 to Highway 24 to Highway 114 from the northeast.