According to forum posts, several hotels in Agios Nikolaos have been recommended by travelers. The Wyndham Grand Crete Mirabello Bay is favored for its proximity to the town and local amenities, including tavernas and beaches. However, some travelers have had negative experiences there, citing dissatisfaction with their stay. Another highly recommended option is the Miramare Resort & Spa, noted for its cleanliness and excellent service, although it is a bit removed from the town center.

Travelers have also praised the Minos Beach Art Hotel, highlighting its convenient location within walking distance to the town and its exceptional facilities, including multiple restaurants and beaches. St. Nicolas Bay Resort is another recommended option, appreciated for its quiet, beautiful setting.

For those considering where to stay, it's suggested to check recent reviews and consider the proximity to town, especially if planning to explore local culture and dining options.

According to forum posts, Agios Nikolaos is served by local bus services that connect it to nearby towns such as Elounda and Plaka. The bus routes have been adjusted due to road works, now excluding central stops like the lake or harbor and directing passengers to embark or disembark at the bus station or Ammoudi.

Some travelers mentioned that for longer distances, such as traveling from Agios Nikolaos to Chania, you would need to transfer buses at Heraklion. The journey to Chania involves a significant travel time of about 4 1/4 hours one way, plus additional waiting time for bus transfers.

For navigating within the town, there is a small local bus that circulates around Agios Nikolaos, which is helpful for short trips within the area. This service provides a convenient option for those staying locally and looking to explore without personal transportation.