I spent 3 nights at the Wynn Macau a few months ago. It seems to be one of the most popular hotels in Macau as it regularly has full occupancy. I can understand why as the rooms are very large and comfortable, and the hotel is well located at the centre of a group of hotels such as Starworld Galaxy, MGM, Mandarin Oriental and Lisboa.
There is a large casino in the ground floor of the casino, and you will see many high rollers losing money like crazy. There is a Starbucks in the casino which is open till very late so that was pretty cool when spending late nights in the casino. I much prefer staying in this part of Macau, as opposed to the large resorts on Taipa Island like the Venetian, which are just too big and cannot handle the large influx of guests, the Wynn Macau offers a much higher level of personalised service.
I would definitely stay at the Wynn Macau in future if i visited Macau.