The Daphne has a good location near the Grand Bazaar. It was recommended by friends. The first night we were housed in an apartment/hotel across the street from the Daphne. Our unit had a kitchen, our friends unit had a roof deck...with a door they couldn't lock. They were on the top floor with no elevator. The two nights we spent in the Daphne proper were great. There is an old mosque ruin right outside the hotel and a lovely view of the Bosphorus beyond.
The people running the hotel were very accommodating and helpful. The breakfast, included, was a nice buffet with a nice variety. 24 hour desk.