I would post this in the Orlando forum.
I know some hotels have car rental agencies located in the lobby. Maybe one is near your hotel, or if you use Enterprise rental car, they will give you a ride back to the hotel if you find a location close enough. Call them, as I have used their service to a home, but not to a hotel.
I think usually for one way, Enterprise only lets you drop off at hotels. Avis however do let you do one way to various locations, my parents always use them to tour the states. Maybe give them a try?
Thanks Jess - I have in fact booked with Avis as they are about 2 miles away from our destination in Orlando.
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