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transportation from Mersin to Istanbul

what are the good option of traveling from Mersin to Istanbul?

a- is the bus clean and comfortable , how many hours the trip takes and what is the cost of a ticket?

b- same to the train.....

c- is it better to take a taxi and how mush should cost?

d- or take a plain from Adana airport is the best way ?!

any other options are there?