Perched on the banks of the wide Swan River, between the Indian Ocean and the sands of the Nullarbour Desert, Perth is one of the world's most isolated cities, yet still boasts an active beach scene and smokin’ nightlife. Family-friendly Cottesloe is brimming with swimmers, surfers and snorkelers. Head north to Scarbourough for a spirited beachside club scene. Coo at cute marsupials on ferry-accessible Rottnest Island, and don’t miss the views from King's Park and Botanic Gardens.

Fremantle (Freo), Perth’s maritime center, offers a pleasant change of pace from the nearby state capital. From the Victorian Fremantle Markets to the convict-built History Museum to the strikingly modern Maritime Museum, Fremantle is an elegant and energetic spot. Head south and enjoy patio dining on the Cappuccino Strip, famous for its great beaches and boisterous nightlife.

Lovely, laid-back Melbourne has something for everyone: family fare, local and international art, haute boutiques, multicultural dining, Australian and Aboriginal history, spectator sports, and pulsing, swanky nightlife. Cruise on the free City Circle Tram loop to check out unique attractions like the Royal Botanical Gardens and the Healesville Sanctuary, which buzzes with local animal species.

Perched on Tasmania’s southeastern coast, the lively city of Hobart is a unique mash-up of the 19th and 21st centuries. The waterfront cafes, restaurants and studios of the largest city in Tasmania are housed in centuries-old converted warehouses that overlook a harbour bustling with yachts and fishing boats. An active arts scene, vibrant nightlife and leisurely daytime pace add to the city’s charm.

City slickers, culture vultures and beach bums alike fall in love with Sydney. Hang ten at famed Bondi Beach or stroll the calmer sands of Coogee.  Cash burning a hole in your pocket? You’ll find great shopping in the Rocks district and along George and Pitt Streets. Climb to the top of the Harbour Bridge or take a skywalk on Sydney Tower for a 360-degree view of the city. But whatever you do, don’t leave town without cuddling the koalas in the Taronga Park Zoo—they’re ridiculously adorable.

Australia’s most popular spa destination is a gorgeous beachside haven of relaxation, boasting top wellness centres and pristine beaches. Indulge your body in a mud bath, body wrap or soft coral scrub. Whether you choose to be pampered in an open-air pavilion or a private cabana, your perfect spa experience can be found in Palm Cove.

Singapore is known as a bustling metropolis that also happens to be one of the cleanest and safest cities of its size in the world. (Just make sure you heed the local laws—something like spitting in the street might merely be considered rude in your hometown, but here, it carries a severe penalty.) You'll find historic sites like the Thian Hock Keng temple, superlative shopping (including gargantuan malls) and numerous beaches.

The cultural hub of Malaysia, Kuala Lumpur is visually defined by the iconic Petronas Twin Towers, which, at 88 stories high, are the tallest twin buildings in the world and a vision of modern architecture. On the flip side, the Sri Mahamariamman is the oldest Hindu temple in Malaysia, its façade a colorful totem pole of iconography. Shopping at the Central Market is a joyful experience that involves haggling, handicrafts, and happiness.

Vietnam's bustling largest city sets the cultural and economic pace for the country. The former Saigon boasts charming French colonial architecture and wide boulevards, usually thronged and choked with traffic. Taxis are an option for seeing the sprawling city. The War Remnants Museum shows the Vietnam War through Vietnamese eyes. Don't miss the impressive Jade Emperor Pagoda. Go to the frenetic Ben Thanh Market for food, flowers or frogs. Tour through the Mekong Delta, past rice paddies and houseboats.

A trip to Hiroshima is best kicked off with a visit to the Hiroshima Peace Memorial Park, which contains a museum, the remnants of buildings destroyed by the 1945 atomic bomb and monuments to the people killed by this nuclear attack. Understanding Hiroshima’s relatively recent devastation is key to fully appreciating its beauty and culture. Visit splendidly rebuilt historic sites like Hiroshima Castle and Shukkei-en Garden, and don’t miss the Itsukushima Shrine on the nearby island of Miyajima.