U.S. citizens still need to jump through a few hoops to visit Cuba, but as visitors from around the world know, this island offers some amazing opportunities for cultural exchange. Havana is a mix of old-world architecture and of-the-moment culture. Head out of the capital city to the small town of Trinidad to see more Spanish colonial architecture. It’s a UNESCO World Heritage Site and a fantastic home base for a visit to the Valley of the Sugar Mills, a pocket of land that formerly served as the centre of Cuba’s sugar industry.

It’s not just for spring-breakers. Cancun, with its golden beaches and perfect climate, is the premiere coastal destination in Mexico. And while there is certainly a 365-day party available for college students, resorts cater well to families and to those seeking solitude. This Yucatan paradise is also the gateway to the ruins of Tulum and Chichén Itzá.

Jamaica is a melting pot of African, Asian, European and Middle Eastern cultures. You'll experience this diversity in its strong crafts tradition, performing arts and distinctive dining options, like ackee and saltfish with roast breadfruit. Take your holiday to new heights at famed cliff jumping spot, Negril Cliffs. Jamaica offers long beaches, protected coves, rugged mountains, waterfalls, caves and sunshine and chances to play in the surf, ride horses and swim with dolphins. Jump in!

Dozens of nightclubs, hundreds of restaurants and some of Mexico's best beaches await you in Puerto Vallarta. The original colonial town still shines through an endless selection of shopping, art galleries, water and land activities, and hotels. Walk the malecon (boardwalk) and just try to take it all in.

Mexico's fastest-growing resort area offers miles of empty desert and deserted beaches. Laid-back nightlife and old-fashioned fun in the sun is the Cabos' lure. Only certain beaches are safe for swimming, however, including Lovers' Beach and the more tempestuous and aptly named Divorce Beach. Whale-watching, hang-gliding, snorkelling, antique-hunting, golf and fishing, Loreto's historic mission, and sport fishing and dining in capital La Paz are other attractions. SuburBaja buses travel the coast.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

Looking to relax in the sun? Palm Springs, with 354 days of sunshine per year, might be the place for you. Relax poolside or visit one of the many area spas… or tour some fantastic examples of mid-century modern architecture.

Welcoming, tolerant Gran Canaria offers a little something for everyone. Families flock to the water parks and beaches of Puerto Rico. Those seeking peaceful escape scamper to Mogan's quiet fishing villages. Gay visitors crowd the bars, restaurants and beaches of Playa del Ingles. Urban attractions are on offer in Las Palmas. Three highways open up the island for those with a rental car or a bus schedule. Prime sites to visit include Iglesia de San Juan Bautista de Arucas and Palmalitos zoo park.

Amsterdam is truly a biker’s city, although pedaling along the labyrinthine streets can get a little chaotic. Stick to walking and you won’t be disappointed. The gentle canals make a perfect backdrop for exploring the Jordaan and Rembrandtplein square. Pop into the Red Light District if you must—if only so you can say you’ve been there. The Anne Frank House is one of the most moving experiences a traveller can have, and the Van Gogh Museum boasts a sensational collection of works.

The largest of Italy’s fresh-water lakes, Lake Garda is located in northeast Italy. Tourists traveling here will find plenty of excursions and activities to keep them entertained year-round—everything from visiting hilly wine regions to exploring 14th-century castles. The towns and communities surrounding Lake Garda offer easy day trips from Venice, easily accessible by car or train. Major sights include the towns of Sirmione (which attracts most Lake Garda visitors thanks to its historic Rocca Scaligiera castle) and Riva del Garda (for the Varone waterfalls located nearby), as well as the region’s hills, which offer numerous hiking trails for adventurous walkers.