Enveloped in the grandeur of the Black Hills, Custer makes the perfect base for your South Dakota vacation, whether you are visiting Custer State Park to learn about Custer's Last Stand, heading up to see the wonder of Mount Rushmore and the yet-unfinished Crazy Horse Memorial, making a motorcycle pilgrimage to Sturgis or spelunking in Wind Cave. Custer itself has much to offer, from family outings at Flintstones Bedrock City to hoe-down dinners at a chuck wagon cookout.

Rapid City has long been considered one of the gateways to the West, and its rich cowboy and Native American heritage is the result. Visitors won't want to miss the area's mammoth outdoor sculptures. There's Mount Rushmore, of course, but work also continues on the nearby Crazy Horse Memorial, which will be the largest sculpture in the world when it is finally completed years down the line. Among the many local attractions are the scenic Black Hills, several nearby cavern systems that offer guided tours and the South Dakota Air and Space Museum.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."