The Ionian Islands are splendid, cinematic paradise. The waters are bluest blue, the sands are achingly silky and smooth. Everything looks heavily Photoshopped. But that's just Mother Nature, in all her unspoiled glory. Zakynthos is the largest of the Ionian Islands, and it's as fruitful as it is beautiful, boasting a bounty of crops like olives and grapes. Music is a huge part of the local culture—you can catch a concert or festival almost any night of the week, and you'll be captivated by the sights and sounds of Zakynthos performers.

Over the centuries, many cultures have added their mark to this prized piece of land. Today, you can experience those influences firsthand by exploring Istanbul’s mahalles (neighbourhoods). From the holy sites of Sultanahmet and the 19th-century European elegance of Beyoğlu to the high fashion of Nişantaşı, the vibrant café society of Kadıköy and the football-loving streets of Beşiktaş, it’s easy to see why travellers say that Istanbul isn’t just one city, but many cities within one.

It’s nicknamed the Eternal City for a reason. In Rome, you can drink from a street fountain fed by an ancient aqueduct. Or see the same profile on a statue in the Capitoline Museum and the guy making your cappuccino. (Which, of course, you know never to order after 11 am.) Rome is also a city of contrasts—what other place on earth could be home to both the Vatican and La Dolce Vita?

Over 15 million gallons of water bubble daily into Budapest's 118 springs and boreholes. The city of spas offers an astounding array of baths, from the sparkling Gellert Baths to the vast 1913 neo-baroque Szechenyi Spa to Rudas Spa, a dramatic 16th-century Turkish pool with original Ottoman architecture. The "Queen of the Danube" is also steeped in history, culture and natural beauty. Get your camera ready for the Roman ruins of the Aquincum Museum, Heroes' Square and Statue Park, and the 300-foot dome of St. Stephen's Basilica.

If you’re visiting Oberammergau in a year ending with zero, it’s all about the Passion Play. Villagers have performed it since the 17th century. It’s seven hours long (thankfully, with an intermission), and about half the townspeople participate in 100+ performances between May and October. And since hundreds of thousands are expected to attend over the course of those performances, if you’re in town, you’ll have company.

Famed throughout Asia for its heady mix of eastern cultures, Penang Island is Malaysia’s prime melting pot. Roadside vendors serve some of the world’s best street food; its national parks offer white-sand beaches and wildlife; and UNESCO-listed George Town is full of colorful heritage houses.