The Greek island of Santorini is a blissful spot for a getaway, and its capital, Fira, is a vision of dramatic cliffs and pristine whitewashed buildings. The Archaeological Museum contains Minoan artifacts from Fira’s ancient foundations, while several churches and monasteries offer a glimpse into the historical and contemporary religious make up of this beautiful village. Exploring the shops and cafes along Fira’s narrow footpaths is a leisurely way to spend an afternoon.

Ios embodies that classic Greek island ambiance—hillside clusters of blue-roofed white buildings, an amphitheatre, golden beaches that spill into the sapphire sea. The spindly windmills of Ios are like something from a storybook, and a visit to the Tomb of Homer (yep, that Homer) is an exercise in awed contemplation. When the sun goes down, party it up at one of Ios’ many electrifying nightspots. Favourites are Astra Cocktail Bar and the (kind of insane) alt-rock scene, The Orange Bar.

Known as the "Island of Colours" thanks to its jewel-coloured waters and building painted in vivid primary tones, the horseshoe-shaped island of Milos floats serenely in the Aegean Sea. It was here that the world-famous Venus de Milo statue was discovered. Though she now holds court at the Louvre, Milos has other beauties to admire. There are dozens of beaches, all different colours and all different combinations of sand, stone and shell. Explore the ancient theatre, catacombs and windmills in Tripiti village, then cap off your day with a cinematic sunset.

There are beaches for everyone on Paros—families, partiers, watersports enthusiasts, honeymooners. Anyone can find their perfect stretch of golden sand. The same breeze that rustles orange and pomegranate trees will power your kitesurfing or windsurfing session. In the capital city of Parikia, make sure to pay your respects at the Byzantine “church of 100 doors” (Panagia Ekatontapillani) and visit the seaside ruins of a medieval castle built from the marble remains of an ancient temple.

Over the centuries, many cultures have added their mark to this prized piece of land. Today, you can experience those influences firsthand by exploring Istanbul’s mahalles (neighbourhoods). From the holy sites of Sultanahmet and the 19th-century European elegance of Beyoğlu to the high fashion of Nişantaşı, the vibrant café society of Kadıköy and the football-loving streets of Beşiktaş, it’s easy to see why travellers say that Istanbul isn’t just one city, but many cities within one.

Cairo’s an ancient city that also happens to be a modern metropolis—it’s one of the biggest cities in the Middle East and has the traffic and noise issues to prove it. But as long as you’re not looking for solitude, Cairo—the City of the Thousand Minarets—is a splendid place to explore Egyptian history and culture. (Editor's note: Our list was compiled before political unrest prompted many countries to issue travel warnings for Egypt. If you're currently planning a trip to Egypt, please consider the risks and monitor your government's travel alerts.)

It’s nicknamed the Eternal City for a reason. In Rome, you can drink from a street fountain fed by an ancient aqueduct. Or see the same profile on a statue in the Capitoline Museum and the guy making your cappuccino. (Which, of course, you know never to order after 11 am.) Rome is also a city of contrasts—what other place on earth could be home to both the Vatican and La Dolce Vita?

Move over, Haussmann and l'Enfant. Beijing's urban planner beat you by a couple of centuries. His name is Kublai Khan. Here, you'll find a wealth of history, both ancient (the Hall of Preserving Harmony, Summer Palace, Forbidden City) and more recent (Chairman Mao Memorial Hall, Tienanmen Square). For the best market experience, choose the Dirt Market over the touristy Silk Market.