Dubbed the Queen City, Charlotte reigns over a 300-square-mile (482-square-kilometre) hodgepodge of neighbourhoods that spin out from the banks of the Catawba River. From brewery-heavy art districts to historical corridors dripping in charm, consider Charlotte a crowd pleaser.

Greenville, South Carolina, is a welcoming place to shop, dine, see historic homes and watch minor-league sports. The city is also home to significant art collections and a vibrant performing-arts scene. Families can enjoy child-friendly activities such as searching for nine bronze mice scattered around the city, visiting the Greenville Zoo, relaxing in the many outdoor spaces and enjoying numerous annual festivals. State parks and Revolutionary and Civil War sites are a short drive away.

The very mention of Tombstone brings to mind images of the lawless Old West, gunfights at the O.K. Corral, epic feuds between the Earps and the Mclaurys and Clantons, Gold Rush fever and the promise of silver and gold. The heritage of the American West is still alive here today, where historic saloons, post offices and the famous Boot Hill cemetery stand restored and painstakingly preserved alongside more modern, tourist-focused recreations of period architecture.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."