Named for legendary explorer, Daniel Boone, Boone, North Carolina retains the pioneer spirit, despite having grown into a busy college town, the home of Appalachian State University. The surrounding area is one of the country's best destinations for outdoor adventures. Walk across the Mile High Swinging Bridge to Grandfather Mountain's Linville Peak, the highest point in the Blue Ridge Mountains, or grab your bike and head to Pisgah National Forest, featuring over 200 miles of exciting trails.

If you’re into eating locally and supporting sustainable agriculture, go to Ashville—and eat, eat, eat. This town of less than 100,000 people has 17 farmers’ markets, and the local restaurant scene is all about taking advantage of the seasonal produce sold there. And don’t miss the area’s microbreweries.

Dubbed the Queen City, Charlotte reigns over a 300-square-mile (482-square-kilometre) hodgepodge of neighbourhoods that spin out from the banks of the Catawba River. From brewery-heavy art districts to historical corridors dripping in charm, consider Charlotte a crowd pleaser.

Rock Hill, the largest city in South Carolina's York County, is a charming college town, with the campus of Winthrop University making up one of its five historic districts. The surrounding area of York County is home to the Carowinds amusement park, an entertainment destination so large that it spans two states. The York County Library hosts the annual Patchwork Tales Storytelling Festival, featuring musicians, storytellers, and artists from all over the world.

Greenville, South Carolina, is a welcoming place to shop, dine, see historic homes and watch minor-league sports. The city is also home to significant art collections and a vibrant performing-arts scene. Families can enjoy child-friendly activities such as searching for nine bronze mice scattered around the city, visiting the Greenville Zoo, relaxing in the many outdoor spaces and enjoying numerous annual festivals. State parks and Revolutionary and Civil War sites are a short drive away.

A romantic wine village located along Germany's Rhein River.