Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

Tulum is relaxation and romance with an ancient angle. Guests can enjoy modern takes on traditional Mayan massage and spa treatments, or sunbathe on gorgeous Yucatan beaches within site of well-preserved ancient ruins. A rare mix of beach, archeology and village, Tulum is a romantic getaway like no other.

With a rich pre-Colombian history, Ecuador's capital was founded on the ruins of an Incan city but offers everything a modern traveller might need. It remains the least-altered historic centre in Latin America and has been designated a UNESCO World Heritage Site. Quito’s important sites include baroque gems like San Francisco and Santo Domingo monasteries, as well as La Compañía church and college. This huge city sprawls across a breathtaking Andean valley surrounded by volcanic peaks.

Everyone who visits Paris for the first time probably has the same punchlist of major attractions to hit: The Louvre, Notre Dame, The Eiffel Tower, etc. Just make sure you leave some time to wander the city’s grand boulevards and eat in as many cafes, bistros and brasseries as possible. And don’t forget the shopping—whether your tastes run to Louis Vuitton or Les Puces (the flea market), you can find it here.

Set on Spain's Costa del Azahar, the fortified city of Peniscola features sprawling Mediterranean beaches and an old town surrounded by medieval castle walls. Cobbled streets wind past museums, restaurants, and white-washed houses, while a nearby nature reserve boasts miles of pristine countryside.

The city of Freiburg im Breisgau sits austerely on the edge of the Black Forest. Home to one of Germany’s oldest universities and a Gothic sandstone cathedral, it’s a hub for academics and medieval history buffs. Chug German suds at a local brewery, then hop a cable car up Schauinsland mountain, where astounding views and a solar observatory await.