This Italian-speaking region in Southern Switzerland is on the border with Italy. Bellinzona is the capital, and Lugano is the most important city in the canton, known for its beautiful waterfront, steep hillsides and gorgeous lake views. Castelgrande is a lovely medieval castle overlooking the city that has recently been restored. The Centovalli Railway is a scenic train that operates between Locarno, Switzerland and Domodossola, Italy, traveling through the breathtaking "Hundred Valleys." Lake Como is nearby, the home of People magazine’s “Sexiest Man Alive,” George Clooney.

The city of Freiburg im Breisgau sits austerely on the edge of the Black Forest. Home to one of Germany’s oldest universities and a Gothic sandstone cathedral, it’s a hub for academics and medieval history buffs. Chug German suds at a local brewery, then hop a cable car up Schauinsland mountain, where astounding views and a solar observatory await.

Lucca's array of wonderfully intact historical sites makes it a must-see stop on any Tuscan itinerary. The mediaeval city walls still stand—you can hike or bike on top of them. Also visit the Duomo di San Martino and the Roman amphitheatre.

The gateway to the Loire Valley, Tours offers plenty to admire in its own right. Gothic architecture, café-lined squares, and manicured gardens conjure up a Parisian atmosphere without the crowds in this university town tucked between the banks of the Loire and Cher rivers.

A small city with big appeal, Bialystok is a charming Polish town. Visit the impressive Branickis' Palace or admire the beautiful 19th-century architecture of Warszawska Street or follow the historic Jewish Heritage Trail. Performances at the Białystok Puppet Theater are fun for the whole family, as is the dining experience at a local milk bar.

The political, scientific, historical, architectural and business centre of Russia, Moscow displays the country's contrasts at their most extreme. The ancient and modern exist side by side in this city of 10 million. Catch a metro from one of the ornate stations to see Red Square, the Kremlin, the nine domes of St Basil's Cathedral, Lenin's Mausoleum, the KGB Museum and other symbols of Moscow's great and terrible past, then lighten up and go shopping in Boulevard Ring, or people-watch in Pushkin Square.

Since the redevelopment of the Inner Harbor in the late 1970s, Baltimore has set the standard for urban renewal. While a good part of the city's action centres around the fun and festive Harbor area, where street entertainers, open-air concerts, fireworks and parades abound, the surrounding neighbourhoods offer all sorts of interesting landmarks, unique shops and delicious restaurants. Wander around Fells Point, the oldest part of Baltimore, reminiscent of an old English village, complete with pubs and cobbled streets. Take the kids to the aquarium and check out the imaginative creations at the American Visionary Art Museum. Or visit the Babe Ruth Birthplace and Museum for an in-depth look at the Great Bambino's life. Baltimore is also renowned for its African-American heritage sites, plus festivals and cultural events that take place throughout the year. From historic places and harbour cruises to family-friendly attractions and fabulous neighbourhoods, Charm City is one of the top tourist destinations in the United States.