Frequented by A-listers and ranked as one of Los Angeles’ trendiest enclaves, West Hollywood is known for its nightlife, upscale shopping areas, destination restaurants, and live-entertainment venues. The area's famed thoroughfares include Sunset Strip and Melrose Avenue.

Everything about Santa Monica sizzles, from hundreds of funky shops and restaurants to more than three miles of white sandy beach, to the multitude of celebrities zipping into the local airport and out on Montana Avenue. The subject of popular songs, movies and television shows ("Baywatch" was one of many filmed here), the city has a vibe like no other. Hollywood haute couture meets surfer chic meets hippie casual, and somehow it all works. A word of advice: ditch the car and walk everywhere. Santa Monica is small and prides itself on being pedestrian- and environmentally friendly. You won't need wheels at the auto-free Third Street Promenade, a stroller's paradise known for its multitude of cinemas, restaurants and street performers. Or at the famous and historic Santa Monica Pier, home to tempting smells from fast-food stalls and the solar-powered, nine-storey high Ferris wheel that has long been a symbol of the city. If your feet start to fail, hop on the electrically powered Tide Shuttle, a bus service that runs along the beach offering great views plus a ride to the artsy Bergamot Station and the Santa Monica Museum of Art, or your next spirited Santa Monica destination.

Known as the home of “the happiest place on Earth,” there’s more to Anaheim than thrilling theme parks. Bring your appetite to the Anaheim Packing District and Centre Street Promenade for some eclectic eateries and award-winning craft breweries. Explore the latest exhibits at the Muzeo Museum and Cultural Centre. Enjoy live music at the all-new House of Blues, now at the Anaheim GardenWalk.

Boardwalk shops on Newport Beach Pier and outdoor mall, Fashion Island, present excellent opportunities to discover the ideal beach wardrobe. Swimming, sunning and boat trips to Catalina Island are on the menu by day, while spectacular sunsets and waterside dining beckon at night.

About an hour south of Los Angeles, Laguna Beach has a spectacular clifftop setting above some of the finest beaches in California. Outdoor enthusiasts can snorkel, scuba dive, body-surf, or hike the trails in nearby Laguna Coast Wilderness Park. A centre for artists, there are a number of special events and festivals,such as the Sawdust Art Festival, Festival of Arts/Pageant of the Masters, Art-A-Fair and Plein Air Painting Invitational. The Laguna Art Museum focuses on California artists. Window shoppers and collectors will enjoy strolling the village’s quaint streets, as well as visiting galleries spotted along Pacific Coast Highway.

Centrally located near all of Southern California’s major cities, Temecula Valley is the region’s wine country — with 40+ wineries offering everything from tours and events to restaurants and early-morning hot air balloon flights featuring panoramic views. Visitors also enjoy a wide range of outdoor recreational activities; the largest casino in the state at Pechanga Resort Casino; and a historic Old Town featuring wooden boardwalks, artisanal shops and restaurants, and a bustling nightlife.

California’s desert regions fascinate visitors with the unexpected. Vast expanses, wide salt flats and ghost towns are on full display in In the quintessential desert at Death Valley National Park. Visit Joshua Tree National Park to see both the Mojave and Colorado desert landscapes, where wildflower blooms offer a spectacular sight every spring. Don’t miss the sculpture gardens and hiking trails of Anza-Borrego Desert State Park.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

Who cares about a little fog (okay, a lot of fog) when there’s so much to do in San Francisco? By day, explore Fisherman’s Wharf and the Aquarium of the Bay, ride a cable car, and stroll around the Presidio; by night, have a fabulous dinner (at a Michelin-starred restaurant or a tiny place in Chinatown), then hit some of the best clubs on the West Coast.

What happens when a "gassy" Englishman rows into town feeling thirsty? A pub is born. And from that a city—in this case Vancouver. Though the pubs are plentiful, food and drink aren’t the only things to take in during your trip. In its 150 years, Vancouver has grown into a cosmopolitan city nestled in the great outdoors. Enjoy the snow-capped mountains, waterfront forests, cityside beaches, Olympic history and the world’s highest suspension bridge. Hipsters welcome. (Don’t worry, they don’t bite.)

We've heard Toronto described as "New York City run by the Swiss," and it's true—you can find world-class theatre, shopping and restaurants here, but the sidewalks are clean and the people are friendly. The best place to start is literally at the top—the CN Tower, the tallest freestanding structure in the Western Hemisphere.

From the Magic Kingdom to magical spa treatments, Orlando sparkles with the promise of adventure. Spend a day exploring the world-famous Disney theme parks or screaming your head off on a Universal Studios roller coaster. For a less adrenaline-pumping afternoon, enjoy the quiet natural beauty of the Harry P. Leu Gardens or enjoy a seaweed scrub at a luxury day spa. Savor fresh and local ingredients at one of Orlando’s James Beard-nominated restaurants.

From the National Mall’s monuments and memorials to vibrant neighbourhoods filled with character and charm, DC is a world-class destination featuring breathtaking views, award-winning hotels and hundreds of free things to do. Experience outstanding performing arts at acclaimed theatres, shop in historic Georgetown, hear great live music at legendary venues, enjoy sporting entertainment from six professional franchises and be dazzled by a flourishing dining scene with Michelin-starred restaurants.

The first time you go to New York, go ahead and be a sight-seer—everyone should visit the Statue of Liberty, the Met, Times Square, etc. But on a return trip, pick a neighbourhood and go deep. You’ll find hole-in-the-wall bars, great delis, quirky shops… exploring the non-touristy side of New York is an incredibly rewarding experience for a traveller.

It seems like most folks have a grandmother, great-uncle or some other distant relative that used to live in Brooklyn, or perhaps a friend that lives there now. In the early 1900s, it was a mecca for immigrants arriving via Ellis Island. A hundred years later, young professionals and artists left pricey Manhattan digs for Brooklyn's cheaper and more expansive space. Neighbourhoods like Brooklyn Heights and Park Slope, which had fallen into disrepair over the years, were restored and reborn as funky enclaves. Walk or bike over the historic Brooklyn Bridge (or ride the subway) to Brooklyn Heights for a stroll along the Promenade and breathtaking views of the Manhattan skyline. Meander through Prospect Park and the Brooklyn Botanical Gardens for a taste of nature in the urban wilds. Catch a performance at the world-famous Brooklyn Academy of Music. From the delicious Italian restaurants of Bensonhurst to the Irish bars that line the avenues of Bay Ridge, from the hotdogs and rollercoasters of Coney Island to the bagels and handball courts of Greenpoint, Brooklyn is a state of mind as well as a dynamic community. Discover why, no matter where people move on to, they remain Brooklynites at heart.

You've got to walk the Freedom Trail the first time you visit Boston. That's just a given. Make sure you step off the line on the pavement, though, and explore some of Boston's fine museums (try the Gardner—art masterpieces displayed in their collector's mansion) and old neighbourhoods (like the North End, where you can get the best cannoli this side of Italy). You can't claim to have experienced real Boston culture, though, unless you've watched a Red Sox game from the bleachers.