The kings of the Wodeyar dynasty set the bar high for the southern cultural capital of Mysore. Ornate palaces and the Gothic St. Philomena's Church with its 175-foot spires pack a visual punch; local institutions keep Carnatic classical music and dance in the public eye. A prominent 11th-century temple sits atop 1,000 steps on the city's outskirts. Dress to the nines and party like a rock star in celebration of Mysore heritage during the lively Dussehra festival, held for 10 days in October/November.

Deep in the foothills of the Western Ghats, Chikmagalur draws in-the-know travellers in search of a green getaway. Located close to the region’s hilltop temples, coffee plantations, and national parks, the district capital's biggest surprise is that it's retained its off-the-beaten-path ambience.

Known as the safari capital of Africa, Nairobi is an energetic, modern city that serves as a fascinating introduction to both wildlife and nightlife. Music clubs pulse with life, shops and markets bustle, and a mélange of restaurants will tempt your palate in this former Maasai watering hole. Top sights include the Karen Blixen Museum, Giraffe Centre and the black rhinos of Nairobi National Park. The compact city centre is safe to walk in and taxis make other areas accessible.

Bali is a living postcard, an Indonesian paradise that feels like a fantasy. Soak up the sun on a stretch of fine white sand, or commune with the tropical creatures as you dive along coral ridges or the colorful wreck of a WWII war ship. On shore, the lush jungle shelters stone temples and mischievous monkeys. The “artistic capital” of Ubud is the perfect place to see a cultural dance performance, take a batik or silver-smithing workshop, or invigorate your mind and body in a yoga class.

It’s nicknamed the Eternal City for a reason. In Rome, you can drink from a street fountain fed by an ancient aqueduct. Or see the same profile on a statue in the Capitoline Museum and the guy making your cappuccino. (Which, of course, you know never to order after 11 am.) Rome is also a city of contrasts—what other place on earth could be home to both the Vatican and La Dolce Vita?

The largest city in Switzerland is a major contemporary art and shopping destination. Important artworks are displayed in the Kunsthaus and the Rietberg Museum. Those who consider shopping an art can hone their skills along Bahnhofstrasse and Niederdorf. Chagall's stained-glass windows in the Fraumünster amaze. Zurich's 500 clubs and bars, including several in swimming pools, pulse with life till the early hours. This city on Lake Zurich has excellent public transport and a free bike-hire system.