Named for legendary explorer, Daniel Boone, Boone, North Carolina retains the pioneer spirit, despite having grown into a busy college town, the home of Appalachian State University. The surrounding area is one of the country's best destinations for outdoor adventures. Walk across the Mile High Swinging Bridge to Grandfather Mountain's Linville Peak, the highest point in the Blue Ridge Mountains, or grab your bike and head to Pisgah National Forest, featuring over 200 miles of exciting trails.

If you’re into eating locally and supporting sustainable agriculture, go to Ashville—and eat, eat, eat. This town of less than 100,000 people has 17 farmers’ markets, and the local restaurant scene is all about taking advantage of the seasonal produce sold there. And don’t miss the area’s microbreweries.

Lafayette is part college town, part natural landscape and part lively urban center. Across the Wabash River in West Lafayette, Purdue University draws a diverse young student population to the city. A walking tour of downtown Lafayette reveals a historic core of Victorian architecture, unique shops and public art. Nature abounds in the city and area parks, including Columbian Park, the Celery Bog wetlands, the Jerry E. Clegg Botanical Garden along Wildcat Creek and Wolf Park in Battle Ground.

With its ideal location on the magnificently rugged Oregon Coast, the entire city of Newport is a natural observatory that offers a number of fun and educational activities for the whole family. Spend the morning exploring tide pools, combing the beach for fossils and spotting marine life in their natural habitats. Then head over to the Oregon Coast Aquarium where you can pet an octopus and walk through a glass tunnel surrounded by sharks. Newport is also home to two lighthouses, one of which is the tallest on the Oregon Coast. Historic Nye Beach, with its colorful cottages and laid-back atmosphere, is the perfect spot for a picnic and a quick rest from all the sightseeing.

While many visitors come for the beaches, arts celebrations and fiestas, San Sebastian-Donostia is serious about its food and drink. The Old Quarter’s narrow, winding streets are full of bars and restaurants, and in the modern city, sidewalk cafes are all around. The city specialises in seafood. Just make sure you know not to expect dinner at 6 or 7 p.m.—that’s much too early in Spain. Instead, tide yourself over with tapas, and enjoy eating and drinking late into the night.