Lusaka, the capital and largest city in Zambia, can be a confusing and chaotic place for visitors not familiar with its unplanned neighborhoods and streets. Busy stores and shopping centers line Cairo Road and the surrounding area. Nearby covered markets sell anything from souvenir figurines to spare engine parts. Just south of Lusaka is the Munda Wanga Environmental Park, which features botanic gardens, a wildlife park and sanctuary, picnic areas, swimming pools, and a relaxing terrace bar.

Known as the safari capital of Africa, Nairobi is an energetic, modern city that serves as a fascinating introduction to both wildlife and nightlife. Music clubs pulse with life, shops and markets bustle, and a mélange of restaurants will tempt your palate in this former Maasai watering hole. Top sights include the Karen Blixen Museum, Giraffe Centre and the black rhinos of Nairobi National Park. The compact city centre is safe to walk in and taxis make other areas accessible.

The Ionian Islands are splendid, cinematic paradise. The waters are bluest blue, the sands are achingly silky and smooth. Everything looks heavily Photoshopped. But that's just Mother Nature, in all her unspoiled glory. Zakynthos is the largest of the Ionian Islands, and it's as fruitful as it is beautiful, boasting a bounty of crops like olives and grapes. Music is a huge part of the local culture—you can catch a concert or festival almost any night of the week, and you'll be captivated by the sights and sounds of Zakynthos performers.

It’s nicknamed the Eternal City for a reason. In Rome, you can drink from a street fountain fed by an ancient aqueduct. Or see the same profile on a statue in the Capitoline Museum and the guy making your cappuccino. (Which, of course, you know never to order after 11 am.) Rome is also a city of contrasts—what other place on earth could be home to both the Vatican and La Dolce Vita?