Camden, Maine is proud to call itself the "Jewel of the Coast." A beautiful seaport town with a harbor full of sail boats, Camden has been used as the setting for so many movies, from Carousel to Peyton Place, that it is what many people think of when they think of New England. With a series of annual festivals running all year round, including the US Toboggan Championships, the Summer HarborArts Juried Arts & Craft Show and Windjammer Weekend, there is always something to do in Camden.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

Desert meets sea in Puerto Penasco, a California Gulf getaway. With its seafood markets, snoozy streets, and sandy beaches, it's easy to see how the port town has retained its traditional charm. There's something for everyone, from nature parks and water sports to upscale resorts.

So close to Rio de Janeiro, yet so different, Ilha Grande is Brazil’s relaxing, undeveloped paradise. Stepping off the ferry to the island is to disconnect from the outside world. No cars, no banks (bring your money!), no ringing phones. It’s all about relaxing in the sun, sailing, swimming, disappearing into spas and reemerging for fresh seafood at one of the 30 small restaurants.