Singapore is known as a bustling metropolis that also happens to be one of the cleanest and safest cities of its size in the world. (Just make sure you heed the local laws—something like spitting in the street might merely be considered rude in your hometown, but here, it carries a severe penalty.) You'll find historic sites like the Thian Hock Keng temple, superlative shopping (including gargantuan malls) and numerous beaches.

Home to nearly nine million and powering an economy that exceeds both Hong Kong's and Thailand's, Osaka packs quite a punch. The confident, stylish city is a shopping hub, with fabulous restaurants and nightlife. It's an ideal base for exploring the Kansai region: Kyoto's World Heritage Sites, Nara's temple and Koya-san's eerie graves are within 90 minutes by train. Top city attractions include the aquarium, Osaka Castle, Universal Studios Japan and the futuristic Floating Garden Observatory.

Tradition collides with pop culture in Tokyo, where you can reverently wander ancient temples before rocking out at a karaoke bar. Wake up before the sun to catch the lively fish auction at the Toyosu Market, then refresh with a walk beneath the cherry blossom trees that line the Sumida River. Spend some time in the beautiful East Gardens of the Imperial Palace, then brush up on your Japanese history at the Edo-Tokyo Museum. Don’t forget to eat as much sushi, udon noodles, and wagashi (Japanese sweets) as your belly can handle.

Perched on the banks of the wide Swan River, between the Indian Ocean and the sands of the Nullarbour Desert, Perth is one of the world's most isolated cities, yet still boasts an active beach scene and smokin’ nightlife. Family-friendly Cottesloe is brimming with swimmers, surfers and snorkelers. Head north to Scarbourough for a spirited beachside club scene. Coo at cute marsupials on ferry-accessible Rottnest Island, and don’t miss the views from King's Park and Botanic Gardens.

Fremantle (Freo), Perth’s maritime center, offers a pleasant change of pace from the nearby state capital. From the Victorian Fremantle Markets to the convict-built History Museum to the strikingly modern Maritime Museum, Fremantle is an elegant and energetic spot. Head south and enjoy patio dining on the Cappuccino Strip, famous for its great beaches and boisterous nightlife.

Brisbane is Queensland’s thriving capital city offering the best of many worlds. Indulge in Brisbane’s flourishing dining scene with a smorgasbord of award-winning restaurants to choose from. Make it a rooftop rendezvous and hop between the city’s many vibrant sky-high bars, or settle in at charming hidden laneway gems. Embrace Brisbane’s iconic blue skies and balmy nights – abseil cliffs, hike to hidden waterfalls, wander exclusive art exhibitions, island-hop or picnic by boat. Or simply relax poolside at one of Brisbane’s luxury hotels. Stay a little longer and explore the Scenic Rim’s World Heritage rainforests or the stunning Moreton Bay filled with pristine islands and wildlife just an hour from the city. Start planning your Brisbane getaway now.

Lovely, laid-back Melbourne has something for everyone: family fare, local and international art, haute boutiques, multicultural dining, Australian and Aboriginal history, spectator sports, and pulsing, swanky nightlife. Cruise on the free City Circle Tram loop to check out unique attractions like the Royal Botanical Gardens and the Healesville Sanctuary, which buzzes with local animal species.

You can fit a lot into a visit to Australia’s capital city. Surrounded by nature parks, Canberra is best known for a vast collection of history and culture that provides a snapshot of the nation. Discover precincts housing, thriving local arts and foodie scenes, family friendly attractions, outdoor experiences and the acclaimed cool-climate wineries that dot the surrounding area.

City slickers, culture vultures and beach bums alike fall in love with Sydney. Hang ten at famed Bondi Beach or stroll the calmer sands of Coogee.  Cash burning a hole in your pocket? You’ll find great shopping in the Rocks district and along George and Pitt Streets. Climb to the top of the Harbour Bridge or take a skywalk on Sydney Tower for a 360-degree view of the city. But whatever you do, don’t leave town without cuddling the koalas in the Taronga Park Zoo—they’re ridiculously adorable.