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Second location near the Inner Harbor: 750 East Pratt Street in the Constellation Energy building's ground floor, (410) 528-5373.
Best parking is the garage on the RIGHT SIDE of Lombard Street IMMEDIATELY after turning off President / I-83. Take the elevator to the "Sky Bridge" on the 7th floors, go through the Constellation Energy building to the second set of elevators. Miss Shirley's is on the ground floor.
Ask for a parking discount coupon!
Walking: Head East from the Inner Harbor towards "Little Italy" on the left side of the street. MS's is directly across from the (expensive) Pier V parking garage.