Established by German immigrants in 1853, this is now the key port, transit and business hub of the Lakes District – a good place to replenish supplies, pick up Chilean crafts and get an urban jolt before moving on to more pristine pastures. If you're in the mood to sample some of the famous local salmon, the Angelmo harbor market should be your first stop. From there, it's a short boat ride across to Tenglo Island for views of snow-capped volcanic peaks. Santiago is a two-hour flight away.